Benefits from freeze-all embryo strategy in older IVF patients
. Conventional IVF protocols involve the transfer of a fresh embryo to the uterus during the same cycle in which the eggs were collected and freezing extra embryos for future use. A novel approach to improving IVF outcomes has recently emerged in which all embryos generated from an egg collection cycle are electively frozen and transferred in a subsequent cycle. This "freeze-all" approach, initially developed as a strategy for minimising risk of ovarian hysperstimulation syndrome (OHSS) in high risk patients, also addresses concerns that some have raised that the drugs used for ovarian stimulation during IVF may have a negative impact on the uterine receptivity of some patients. In theory, therefore, waiting until a later "natural" cycle for embryo transfer should improve outcomes in these patients; however, evidence supporting this claim is limited.
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